Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation.
نویسندگان
چکیده
Efficient palladium-catalysed cascade cyclisation to form spiroindoles is developed. Treatment of indoles bearing a propargyl chloride side chain at the 3-position with various external nucleophiles in the presence of a catalytic amount of Pd2(dba)3·CHCl3/dppb and Cs2CO3 in THF gives fused tetracyclic spiroindoles in moderate to good yields.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 50 3 شماره
صفحات -
تاریخ انتشار 2014